Outline of approach

The essence of our approach is an iterative cycle of experiment-based modeling and model-driven experimental testing spanning multiple levels of complexity (from cell lines to mouse models and patients). We have chosen to focus on TNBC and ILC as specific breast cancer subtypes for which there is an urgent need for targeted therapy. We will focus on the MAPK and PI3K pathways, since these are frequently implicated in these subtypes of breast cancer.