model building

Construction an in silico MAPK and PI3K pathway model

Panel A: Existing upstream models (blue) are extended with core components (grey) to bridge the gap to relevant cellular phenotypes (P1, P2, P3). Addition of strongly associated components based on external databases (green) produces the Expanded network. Panel B: Components of the Expanded network which are putative cancer proteins are depicted in red. Panel C depicts the Extended network: the core network, the canonical PI3K and MAPK signaling components and the putative cancer proteins.